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Stress induces an increased hexose uptake in cultured cells

✍ Scribed by A. P. Warren; M. H. James; D. E. Menzies; C. C. Widnell; P. A. Whitaker-Dowling; C. A. Pasternak

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
909 KB
Volume
128
Category
Article
ISSN
0021-9541

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✦ Synopsis

Temperature-sensitive mutants have revealed a region of the herpes simplex virus 1 genome that affects both the uptake of hexose and the synthesis of heat shock proteins. Other inducers of heat-shock proteins, namely heat shock itself and arsenite, likewise induce an increased uptake of hexose. The increased uptake, like that induced by insulin, is insensitive to the presence of actinomycin D or cycloheximide. It is concluded that an increased hexose uptake, reflecting an activation or relocation of existing hexose transport protein, is a general biochemical response of stressed cells.

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