Stress in the emergency room: a simple leukocyte to glass adhesion test provides a diagnostic tool to differentiate between stress and infection/inflammation related leukocytosis
✍ Scribed by Fier, Gill ;Sasson, Yifaat ;Rogovsky, Ori ;Liberman, Eliezer ;Leibovitz, Eyal ;Halperin, Pinchas ;Sarov, Jack ;Arber, Nadir ;Sarafian, Farjad ;Seltzer, David ;Berliner, Shlomo
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 91 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0748-8386
No coin nor oath required. For personal study only.
✦ Synopsis
In order to discriminate between stress-induced leukocytosis and an infection/in¯ammation-related one, we have used a modi®ed leukocyte adhesiveness/aggregation test (LAAT) to examine the adhesive properties of white blood cells towards glass surfaces. A highly signi®cant p 5 0.00001 dierence was noted between the percent of aggregated cells found in a group of patients with various conditions of infection/in¯ammation 22.9 + 6.4% and those with stress 7.5 + 1.4%. The corresponding dierence between the total white blood cell count in the peripheral blood of these two groups 16Y547 + 3289 and 14Y114 + 4898 cells per mm 3 , respectively) was not signi®cant. The dierence in total leukocytes adhered to the glass in the two groups 445 + 136 vs 228 + 72 cells per high power ®eld) that were determined along the slide was also highly signi®cant p 5 0.00001. Thus, a simple glass slide technique might be of clinical utility for an eective, rapid and inexpensive means of discrimination between stress and infection/ in¯ammation related leukocytosis.