An in silico structure-based ligand design approach resulted in the identification of the first non-peptidic small molecule able to inhibit protein-protein interactions between 14-3-3 and c-Abl. This compound shows an anti-proliferative effect on human leukemia cells either sensitive or resistant to
β¦ LIBER β¦
Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis
β Scribed by Pendergast, Ann Marie
- Book ID
- 109911414
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 166 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1465-7392
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