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Streptozotocin prevents development of nitrosamine-induced pancreatic cancer in the syrian hamster

✍ Scribed by Richard H. Bell Jr.; David S. Strayer

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
706 KB
Volume
24
Category
Article
ISSN
0022-4790

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✦ Synopsis

Administration o f the nitrosamine carcinogen N-nitroso-bis (2-oxopropy 1) amine (BOP) by subcutaneous injection (5 mg/kg/week) led to the development of invasive pancreatic ductular adenocarcinoma in 100% of normal Syrian hamsters by 24 weeks. Pretreatment of a second group of hamsters with the beta-cell toxin streptozotocin in a diabetogenic dose (50 mg/kg i.p x 3 ) completely prevented the development of pancreatic cancer when BOP was subsequently administered. The mechanism of blockade by streptozotocin is unknown. This study suggests the potential importancc of the endocrine pancreas in exocrine pancreatic carcinogenesis

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