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Streamlined synthesis of substituted 2-Aminothiazoles using tandem precipitative and polymer-assisted reactions

โœ Scribed by Young K. Yun; Simon S. W. Leung; John A. Porco Jr.

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
287 KB
Volume
71
Category
Article
ISSN
0006-3592

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โœฆ Synopsis

The tactical combination of classical product precipitation and subsequent modification of precipitated products using polymer-assisted transformations has been employed in the preparation of substituted 2-aminothiazole derivatives. 2-aminothiazoles were precipitated in parallel as hydrobromide monohydrate salts, directly redissolved, and reacted further using polymersupported reagents to afford free-based 2-aminothiazoles, aminothiazoyloxamates, and aminothiazoylamides.

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