If one were to wait for the perfect set of experimental results before launching a multi-agent chemoprevention or large risk reduction study, the trial would never be launched. On the other hand, non-scientific considerations have led to the premature launching of at least three prominent studies (C
Strategy for design of clinical trials of chemopreventive agents
β Scribed by Stimson P. Schantz; Waun Ki Hong; Charles W. Boone; Gary J. Kelioff
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 108 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0730-2312
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
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Approaches to the development and marketing approval of cancer chemopreventive agents have been described by a Working Group from the National Cancer Institute and the Food and Drug Administration in a recent publication [l]. The approaches described do not constitute regulatory requirements, but ra
We have studied aspirin as a potential chemopreventive for colorectal cancer, completing Phase I studies on aspirin pharmacology and potential biomarker assays (prostaglandins, PGE 2 and PGF 2β£ and cyclooxygenase modulation) in normal human subjects. These studies have determined the optimal dose of