Strategy for contra-thermodynamic radical-chain epimerisation of 1,2-diols using polarity-reversal catalysis

✍ Scribed by Hai-Shan Dang; Brian P. Roberts

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 92 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01502-1

✦ Synopsis

Polarity-reversal catalysis by thiols has been applied to provide an efficient method for the conversion of appropriate 1,2-diols into less or similarly stable diastereoisomers by epimerisation of their acetonides under radical-chain conditions.