Experience with sirolimus (SRL)-based immunosuppression following orthotopic liver transplantation (OLT) is rapidly accumulating. In combination with calcineurin inhibitors (CNIs), SRL may reduce the incidence of acute rejection and lower overall required drug levels. This study sought to quantify l
Strategies of Immunosuppression for Liver Transplant Recipients With Hepatocellular Carcinoma
✍ Scribed by J.F. Castroagudín; E. Molina-Pérez; R. Ferreiro-Iglesias; E. Varo-Pérez
- Book ID
- 116936877
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 98 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0041-1345
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Liver transplantation is an important treatment option for selected patients with nonresectable hepatocellular carcinoma (HCC). Several reports have suggested a lower risk of posttransplant tumor recurrence with the use of sirolimus and a higher one with calcineurin inhibitors, but the selection of
Sirolimus (SRL) is a novel immunosuppressant with antitumor properties. We performed a meta-analysis to determine whether SRL can improve patient survival and decrease the risks of tumor recurrence in patients with a pretransplant diagnosis of hepatocellular carcinoma (HCC). We searched databases fo