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Strategies for the phase editing of relayed responses in 2D HMQC-TOCSY spectra

✍ Scribed by Ronald C. Crouch; Timothy D. Spitzer; Gary E. Martin

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
280 KB
Volume
30
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

An NMR technique for the determination of proton vicinal couplings relayed at the carbon chemical shift is presented. With this technique, which is an extension of DEPT‐HMQC‐TOCSY, it is possible to generate phaseedited 2D NMR data in which the ^1^H^13^C relayed responses differ in phase as a function of the proton multiplicity of the carbon from whose proton(s) the response originates. A simple pulse scheme is presented to allow further simplification of the spectrum by eliminating the direct ^1^H^13^C correlations. Thus, responses arising from methines or methyls will be of opposite phase from responses originating from methylenes; direct correlations are eliminated to minimize congestion. An example is presented with the cardiac drug digoxin.

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