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Strategies for the chemoenzymatic preparation of optically active 1-alkyn-3-ols

✍ Scribed by B.I. Glänzer; K. Königsberger; B. Berger; K. Faber; H. Griengl

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
428 KB
Volume
54
Category
Article
ISSN
0009-3084

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✦ Synopsis

A series of (R)-and (S)-l-alkyn-3-ols, chiral building units for the synthesis of leukotrienes and pheromones, were prepared via enantioselective hydrolysis of their racemic esters. While the majority of biocatalysts employed (lipases, fermenting or freezedried microorganisms) failed in discriminating between enantiomers, lyophilized cells of baker's yeast (Saccharomyces cerevisiae Hansen) gave (S)-l-alkyn-3-ols and their corresponding (R)-esters with > 90% e.e.

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