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Strategies for targeted nonviral delivery of siRNAs in vivo

✍ Scribed by Sang-Soo Kim; Himanshu Garg; Anjali Joshi; N. Manjunath

Book ID
116758225
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
559 KB
Volume
15
Category
Article
ISSN
1471-4914

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Successful gene therapy depends on the development of efficient delivery systems. Although pDNA and ODN are novel candidates for nonviral gene therapy, their clinical applications are generally limited owing to their rapid degradation by nucleases in serum and rapid clearance. A great deal of effort