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Strand scission in DNA induced by quercetin and Cu(II): Role of Cu(I) and identification of free radical intermediates.

โœ Scribed by Fabeha Fazal; Arshad Rahman; M.Said Ahmed; Julie Greensill; K. Ainley; J.H. Parish; S.M. Hadi


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
65 KB
Volume
43
Category
Article
ISSN
0162-0134

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Gossypol, a polyphenolic binaphthyl dialdehyde found in cotton seeds, is a dietary mutagen and a potential male contraceptive. In the presence of CdII), gossypol caused breakage of supercoiled plasmid pBR322 DNA. The products were relaxed circles or a mixture of these and linear molecules. Other met