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Strain-specific effects of antidepressants on escape deficits induced by inescapable shock

✍ Scribed by Nola Shanks; Hymie Anisman

Publisher
Springer
Year
1989
Tongue
English
Weight
917 KB
Volume
99
Category
Article
ISSN
0033-3158

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This experiment investigated the effect of antidepressants on the escape deficit induced by inescapable shock. Following exposure to escapable shock, rats received a single injection of either tricyclic antidepressants (imipramine, desipramine), an atypical antidepressant (nomifensine), or saline. I

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The present study was undertaken to investigate the possible involvement of a noradrenergic and opioid mediation of the reversal by tricyclic antidepressants of escape deficits produced by inescapable shock pretreatment. Rats were first exposed to 60 inescapable shocks (15 s duration, 0.8 mA, every