Strain-Dependent Susceptibility to Radiation-Induced Mammary Cancer Is a Result of Differences in Epithelial Cell Sensitivity to Transformation

Intrinsic resistance to apoptosis of col

Intrinsic resistance to apoptosis of colon epithelial cells is a potential determining factor in the susceptibility of the A/J mouse strain to dimethylhydrazine-induced colon tumorigenesis

✍ Karine Oumouna-Benachour; Mustapha Oumouna; Mourad Zerfaoui; Chetan Hans; Kennet 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB

## Abstract Alterations in the delicate balance between cell proliferation and cell death disrupt colon homeostasis and serve as determining factors in colon tumorigenesis. The two mouse strains, AKR/J (resistant) and A/J (susceptible), have been widely used as models for dimethylhydrazine‐induced