Strain-dependent expression of endogenous mouse-tropic leukemia viruses in chemically induced murine leukemias

✍ Scribed by Takeshi Odaka

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: French
• Weight: 461 KB
• Volume: 16
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910160412

✦ Synopsis

Abstract

The effects of two chemical carcinogens, nitrosobutylurea and 7,12‐dimethylbenz‐(a)anthracene, on the expression of endogenous N‐ and B‐tropic viruses were studied. The mice used were from two inbred strains, C57BL/6 and DDD‐FV^r^, and from 13 partially inbred strains derived from the cross of C57BL/6 with DDD‐FV^r^. These mouse strains are classified into three groups by the pattern of expression of endogenous viruses in normal, aged mice: (1) negative for both viruses; (2) positive for N‐tropic virus only; and (3) positive for both viruses. Mice were given the carcinogens, and were tested at various intervals by the UV‐XC procedure for the viruses in the spleens and other enlarged organs. Irrespective of the presence or absence of leukemias, the carcinogen‐treated mice showed the same pattern of expression of endogenous viruses as that of non‐treated normal mice. It can be concluded that the activation of the endogenous viruses is dependent on the mouse strains and that the growth of the activated viruses is not a necessary step for the chemical induction of leukemias.