✦ LIBER ✦
Storable and Air-Stable Zirconium Complex-Catalyzed Highly Enantioselective Darzens Reaction of Diazoacetamide with Aldehydes
✍ Scribed by Long He; Wei-Jun Liu; Lei Ren; Tao Lei; Liu-Zhu Gong
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 163 KB
- Volume
- 352
- Category
- Article
- ISSN
- 1615-4150
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✦ Synopsis
Abstract
An asymmetric Darzens reaction of aldehydes with diazo‐N,N‐dimethylacetamide (3) catalyzd by an air‐stable and storable chiral zirconium Lewis acid catalyst, which is formed from 3,3′‐diiodobinaphthol and tetrabutoxyzirconium, gives solely the cis‐glycidic amides in high yields with excellent enantioselectivity (up to 97% yield, >99% ee).