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Stoichiometric, Catalytic, and Enantioface-Selective Hydrogenation of CN Bonds by an Ionic Mechanism

✍ Scribed by Magee, Matthew P.; Norton, Jack R.


Book ID
126254792
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
47 KB
Volume
123
Category
Article
ISSN
0002-7863

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## Abstract The development of Ir‐catalyzed asymmetric hydrogenation of α‐amino‐β‐keto ester hydrochlorides is described. This reaction proceeds through a dynamic kinetic resolution to produce __anti__‐β‐hydroxy‐α‐amino acid esters in a high diastereo‐ and enantioselective manner. Mechanistic studi