✦ LIBER ✦

Stochastic Effects in Intercellular Calcium Spiking in Hepatocytes

✍ Scribed by M.E. GRACHEVA; R. TORAL; J.D. GUNTON

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 497 KB
Volume: 212
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.2001.2362

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✦ Synopsis

We carry out a Monte Carlo simulation of stochastic e!ects for two models of intercellular calcium wave propagation in rat hepatocytes. Both models involve gap junction di!usion by a second messenger. We "nd that, in general, the stochastic e!ects improve agreement with experiment, for a reasonable choice of model parameters. Both stochastic models exhibit baseline #uctuations and variations in the peak heights of Ca>. In addition, we "nd for one model that there is a distribution of latency times, rather than a single latency time, with a distribution width which is comparable to the experimental observation of spike widths. We also "nd for the other model with low gap junction di!usion that it is possible for cell multiplets to oscillate independently initially, but to subsequently become synchronized.

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