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STK11 Domain XI Mutations: Candidate Genetic Drivers Leading to the Development of Dysplastic Polyps in Peutz-Jeghers Syndrome

✍ Scribed by Wang, Zhiqing; Wu, Baoping; Mosig, Rebecca A.; Chen, Yulan; Ye, Fei; Zhang, Yali; Gong, Wei; Gong, Lanbo; Huang, Fei; Wang, Xinying; Nie, Biao; Zheng, Haoxuan; Cui, Miao; Wang, Yadong; Wang, Juan; Chen, Chudi; Polydorides, Alexandros D.; Zhang, David Y.; Martignetti, John A.; Jiang, Bo

Book ID: 126611345
Publisher: John Wiley and Sons
Year: 2014
Tongue: English
Weight: 602 KB
Volume: 35
Category: Article
ISSN: 1059-7794
DOI: 10.1002/humu.22549

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## Abstract Germ‐line mutations in the serine‐threonine kinase gene __STK11__ (__LKB1__) cause Peutz–Jeghers syndrome (PJS), a rare autosomal dominantly inherited disease, characterized by hamartomatous polyposis and mucocutaneous pigmentation. __STK11__ mutations only account for about half of PJS