Stimulus-transcription coupling and immediate-early genes: Correlations and molecular mechanisms
β Scribed by Michael J. Iadarola
- Book ID
- 119587764
- Publisher
- Elsevier Science
- Year
- 1994
- Weight
- 362 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1058-9139
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Long-term changes in gene expression appear to be critical to the formation of memory, but little is known about its stimulus-transcription coupling. Numerous studies in the last decade, by focusing on unraveling this signal transduction pathway, have investigated the potential role of the immediate
## Abstract The immediateβearly gene __Zif268__ is a member of the Egr family of inducible transcription factors. Data from gene expression studies have suggested that this gene may play a critical role in initial triggering of the genetic machinery that has long been considered a necessary mechani