Stimulatory role of transforming growth factors in multistage skin carcinogenesis: Possible explanation for the tumor-inducing effect of wounding in initiated nmri mouse skin
✍ Scribed by Gerhard Förstenberger; Michael Rogers; Ruben Schnapke; Georg Bauer; Petra Höufler; Friedrich Marks
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 702 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Mechanical wounding provides a convertogenic ("stage I tumor-promoting") stimulus in initiated NMRI mouse skin, indicating that this stage of carcinogenesis can be entirely controlled by endogenous factors. A search for such factors led to the finding that both platelet-derived Epstein-Barrvirus-inducing factor (EIF), alias human TGFB, and porcine TGFP, exhibited-upon intracutaneous injection-convertogenic efficacy in initiated NMRI-mouse skin in vivo provided that their injection was combined with a single topical application of the non-convertogenic tumor promoter I2-0-retinolyphorbol-13-acetate (RPA). Since TGFP inhibits epidermal cell proliferation, the RPA treatment is thought to provide a mitogenic stimulus required for conversion. The RPA treatment can be replaced by intracutaneous injection of transforming growth factor a (TGFa). These results indicate that the stage of conversion consists of two components, one of which is related to mitogenesis (RPA or TGFa), the other to a still unknown activity exhibited by TGFB-like factors. Thus, endogeneous factors with the quality of "wound hormones" may be involved in multistage skin carcinogenesis. This finding could explain the convertogenic effect of skin wounding.