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Stimulatory effect of α-synuclein on the tau-phosphorylation by GSK-3β

✍ Scribed by Fumitaka Kawakami; Minori Suzuki; Naoki Shimada; Go Kagiya; Etsuro Ohta; Kei Tamura; Hiroko Maruyama; Takafumi Ichikawa


Book ID
111314148
Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
596 KB
Volume
278
Category
Article
ISSN
1432-1327

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## Abstract Neuropathological studies have demonstrated that the presence of neurofibrillary tangles (NFTs) is one of the most prominent pathologic characteristics of Alzheimer's disease (AD). The microtubule‐associated protein tau is the major component of NFTs, and its abnormal hyperphosphorylati