Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen
✍ Scribed by Steffen Oesser; Jürgen Seifert
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 248 KB
- Volume
- 311
- Category
- Article
- ISSN
- 0302-766X
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We have analyzed the distribution of type II collagen N-and C-propeptides in the cell layers and culture medium of bovine articular chondrocyte pellet cultures. Two splice variants of the type II collagen N-propeptide were detected by immunoblotting and immunoassay, using a new anti-peptide antibody
## Abstract Type II collagen is a major protein that maintains biological and mechanical characteristics in articular cartilage. Focal adhesion kinase (FAK) is known to play a central role in integrin signaling of cell–extracellular matrix (ECM) interactions, and chondrocyte–type II collagen intera
## Abstract The goal of this study was to examine the simultaneous effects of mechanical compression of chondrocytes on mRNA expression and macromolecular synthesis of aggrrecan and type‐II collagen. Bovine cartilage explants were exposed to different magnitudes and durations of applied mechanical