𝔖 Bobbio Scriptorium
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Stimulation of Tumor-Cell Respiration by Inhibitors of Pyruvate Kinase

✍ Scribed by Mario GOSALVEZ; Luisa LÓPEZ-ALARCÓN; Socorro GARCÍA-SUAREZ; Antonio MONTALVO; Sidney WEINHOUSE

Book ID
115114504
Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
702 KB
Volume
55
Category
Article
ISSN
1432-1327

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✍ Gilles A. Spoden; Sybille Mazurek; Dieter Morandell; Nicole Bacher; Michael J. A 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 505 KB

## Abstract Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2‐PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affinity. The transition between both conformations contributes to the co