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Stimulation of transforming growth factor-β1 transcription by cyclosporine

✍ Scribed by Y. Prashar; A. Khanna; P. Sehajpal; V.K. Sharma; M. Suthanthiran

Book ID
118323623
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
493 KB
Volume
358
Category
Article
ISSN
0014-5793

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Following exogenous administration of transforming growth factor-pl (TGF-PI) polypeptide to the human osteosarcoma cell line TE-85, we observed a 2to 6-fold stimulation of steady-state TGF-PI mRNA. The stimulation was dose-and time-dependent, as judged from Northern blot hybridization analyses. A 2t