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Stimulation of the globus pallidus internus for childhood-onset dystonia

✍ Scribed by Giovanna Zorzi; Carlo Marras; Nardo Nardocci; Angelo Franzini; Luisa Chiapparini; Elio Maccagnano; Lucia Angelini; Dario Caldiroli; Giovanni Broggi

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 74 KB
Volume: 20
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20510

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✦ Synopsis

Abstract

We report the results of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 12 patients with childhood‐onset generalized dystonia refractory to medication, including 3 patients with status dystonicus. There were 8 patients who had DYT1‐negative primary dystonia, 1 had DYT1‐positive dystonia, and 3 had symptomatic dystonia. Stimulation was effective in all but 1 patient. Dystonic postures and movements of the axis and limbs responded to DBS to a greater extent than oromandibular dystonia and fixed dystonic postures. These findings provide further evidence that pallidal stimulation is an effective treatment for intractable childhood‐onset dystonia, including status dystonicus, and together with previous findings, suggest that it should be considered the treatment of choice for these conditions. © 2005 Movement Disorder Society

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