Stimulation of T cells by autologous mononuclear leukocytes and epidermal cells in psoriasis

✍ Scribed by R. E. Schopf; A. Hoffmann; M. Jung; B. Morsches; K. Bork

• Publisher: Springer-Verlag
• Year: 1986
• Tongue: English
• Weight: 569 KB
• Volume: 279
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00417528

✦ Synopsis

Based on reports suggesting aberrant cellmediated immunity and altered infiltration of immunocompetent cells into the skin in psoriasis, we studied the stimulation of T cells by autologous non-T mononuclear ieukocytes (autologous mixed lymphocyte reaction, AMLR) and by epidermal cells isolated from iesional and clinically uninvolved skin in psoriasis (autologous mixed epidermal cell lymphocyte reaction, AMECLR)

. Age-and sex-matched individuals served as controls. We found that the AMLR in psoriasis (n = 11) was similar to that in healthy controls (n = 16); furthermore, cell proliferation was alike in the presence of either 5% AB-serum or antologous serum. By contrast, while the AMECLR in healthy controls (n = 9) resembled that in psoriatics employing epidermal cells from univolved skin, epidermal cells from lesional sites (n = 10) induced a significantly higher proliferation of autologous T cells in the AMECLR (P < 0.01). We conclude that the in vitro stimulation of T cells by non-T mononuclear leukocytes is normal in psoriasis and is not regulated by autologous serum. Lesional psoriatic epidermal cells, however, are more active in stimulating autologons T cell proliferation than cells from univolved psoriatic or normal epidermis.