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Stimulation of subthalamic nucleus alleviates tremor in Parkinson's disease

โœ Scribed by P Krack; P Pollak; P Limousin; A Benazzouz; AL Benabid


Book ID
117311024
Publisher
The Lancet
Year
1997
Tongue
English
Weight
48 KB
Volume
350
Category
Article
ISSN
0140-6736

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Treatment of tremor in Parkinson's disea
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## Abstract The recent resurgent interest in functional surgery for the treatment of Parkinson's disease (PD) has focused on the effects on akinesia and levodopaโ€induced dyskinesia. Stimulation of the subthalamic nucleus (STN) improves akinesia and rigidity but its effects on tremor have not been s

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The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded t