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Stimulation of peripheral blood and intestinal mucosa cells by synthetic CpG oligodeoxynucleotides

✍ Scribed by Fabrice Jugdé; Christine Boissier; Brigitte Birebent; Nicolas Vu; Pierre-Nicolas D'halluin; Nathalie Rioux-Leclercq; Jean-François Bretagne; Gilbert Semana; Denis Heresebach


Book ID
116530318
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
382 KB
Volume
65
Category
Article
ISSN
0198-8859

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## Abstract The immune system of vertebrates detects bacterial DNA as a “danger signal” based on the presence of unmethylated CpG motifs. We examined whether oligodeoxynucleotides (ODNs) with CpG motifs (CpG‐ODNs) also induce mobilization of hematopoietic progenitor cells (HPCs). Mice challenged wi