Stimulation of NMDA receptors activates calpain in cultured hippocampal slices
β Scribed by del Cerro, Sonia; Arai, Amy; Kessler, Markus; Bahr, Ben A.; Vanderklish, Peter; Rivera, Santiago; Lynch, Gary
- Book ID
- 122420375
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 404 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0304-3940
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π SIMILAR VOLUMES
Activated calpain I immunoreactivity (76 kDa band) was detected in membranes prepared from rat brain hippocampal slices using a polyclonal antiserum raised against an N-terminus peptide of the cleaved subunit of calpain I. While basal levels of activated calpain I were stable over incubation times,
The pattern of epileptiform activity recorded from a number of in vitro seizure models is age dependent: ictal discharges are observed in immature brain slices while interictal bursts are seen in adult brain slices. This study evaluated the involvement of the N-methyl-D-aspartate (NMDA) receptor in