Microinjection of cholinergic agonists into the substantia nigra is known to elicit increases in eating, drinking and sexual behaviour under appropriate circumstances. It has been suggested that these effects are dependent on stimulation of nigrostriatal dopamine-containing neurones in the substanti
Stimulation of nigrostriatal dopamine neurones by nicotine
โ Scribed by W. Lichtensteiger; F. Hefti; D. Felix; T. Huwyler; E. Melamed; M. Schlumpf
- Book ID
- 118954587
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 670 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0028-3908
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๐ SIMILAR VOLUMES
+)-Pentazocine, a potent sigma ligand that lacks affinity for PCP receptors, produced dose-dependent contralateral circling behavior following microinjections in the substantia nigra of rats. This effect was attenuated by 6-hydroxydopamine (6-OHDA) lesions of ascending dopamine neurons and enhanced
Nigrostriatal dopamine (NSDA) neurons have been hypothesized to play an important regulatory role in neostriatal sensorimotor integration. In order to provide further information on the nature of sensory modulation of NSDA cells, we have examined the pharmacology of the responsiveness of these neuro