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Stimulation of inflammatory responses in vitro and in vivo by lipophilic HMG-CoA reductase inhibitors

✍ Scribed by Peter A Kiener; Patricia M Davis; Judy L Murray; Sonia Youssef; Bruce M Rankin; Mark Kowala


Book ID
117330355
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
891 KB
Volume
1
Category
Article
ISSN
1567-5769

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Apomineβ„’, an inhibitor of HMG-CoA-reduct
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## Abstract Apomine, a novel 1,1 bisphosphonate ester, increases the rate of degradation of HMG‐CoA reductase, inhibiting the mevalonate pathway and thereby blocking cholesterol biosynthesis. We have investigated whether Apomine can induce myeloma cell apoptosis __in vitro__ and modulate myeloma di