✦ LIBER ✦
Stimulation of growth hormone secretion by baclofen in man: Failure to confirm published findings
✍ Scribed by Hameen Markar; John Bennie; Sheena Carroll; Ann Chiswick; Helen Wilson; Guy M. Goodwin
- Book ID
- 102265367
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 316 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0885-6222
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✦ Synopsis
The effects upon growth hormone (GH) secretion of oral baclofen were determined in 20 male volunteers. Doses of either 5 mg or 0.25 mg/ kg (approx. 20 mg) of baclofen were employed. No stimulation of growth hormone secretion could be discerned in the 90 min following ingestion, a result which is in contrast with the findings of a previous study. We conclude that stimulation of GH secretion by baclofen at low doses does not provide a ready assay of GABAB function in man.