Inhibition of IGFBP-5 binding to extrace
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C. Rees; D.R. Clemmons
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Article
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1998
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John Wiley and Sons
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English
⚖ 77 KB
Insulin-like growth factor binding protein-5 (IGFBP-5) is synthesized and secreted by smooth muscle cells (SMC). IGFBP-5 synthesis is stimulated five-to sixfold by IGF-I, and IGFBP-5 has been shown to augment IGF-I-stimulated DNA synthesis in this cell type. The ability of IGFBP-5 to augment the SMC