Studies in vivo using inhibitors of eicosanoid synthesis suggested that prostaglandins may play a role in mediating tumor promotion in liver by agents such as phenobarbital (PB). However, it is not clear whether any stimulation of arachidonic acid metabolism/prostaglandin formation results directly
β¦ LIBER β¦
Stimulation of DNA repair synthesis of rat thymocytes by novobiocin and nalidixic acid in vitro without detectable DNA damage
β Scribed by Karlheinz Tempel; Alfred Spath
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 567 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0340-5761
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## Abstract We have recently shown that TNF is produced in liver rapidly after partial hepatectomy and that TNF can stimulate DNA synthesis of hepatocyte primary culture with its inhibition by interleukin 6 and transforming growth factorβΞ², indicating a pivotal role of TNF and TNFβdriven cytokine i