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Stimulation of cellular proliferation and differentiation in the intact and regenerating planarianDugesia(G) tigrina by the neuropeptide substance P

✍ Scribed by Saló, Emili ;Baguñà, Jaume

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 635 KB
Volume: 237
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402370117

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✦ Synopsis

The neuropeptide substance P (SP) is shown to be a potent mitogen for intact and regenerating planarians. At nanomolar concentrations, SP markedly enhances cellular proliferation causing an increase in the mitotic index and in the number of blastema cells. Moreover, albeit to a lower extent,

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