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Stimulation of Cdx1 by oncogenic β-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein

✍ Scribed by Claire Domon-Dell; Jean-Noël Freund


Book ID
117104157
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
216 KB
Volume
518
Category
Article
ISSN
0014-5793

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## Abstract The loss of E‐cadherin expression and the translocation of β‐catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, β‐catenin binds to the TCF/LEF‐1 (T‐cell factor/ lymphoid enhancer factor) transcription factor family result