Stilbene-Based Inhibitors of Estrone Sulfatase with a Dual Mode of Action in Human Breast Cancer Cells.

Stilbene-Based Inhibitors of Estrone Sul

Stilbene-Based Inhibitors of Estrone Sulfatase with a Dual Mode of Action in Human Breast Cancer Cells

✍ Georg Walter; Renate Liebl; Erwin von Angerer 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 156 KB 👁 1 views

## Abstract Estrone sulfate (E1S) is an endogenous prodrug that delivers estrone and, subsequently, estradiol to target cells, after hydrolysis by the enzyme estrone sulfatase, which is active in various tissues including hormone‐dependent breast cancer. Blockade of this enzyme should reduce the es