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Stiff-persons' syndrome associated with thymoma and subsequent myasthenia gravis

✍ Scribed by Anthony P. Nicholas; Anjan Chatterjee; Muoi M. Arnold; Gwendolyn C. Claussen; George L. Zorn Jr; Shin J. Oh

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 289 KB
Volume: 20
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199704)20:4<493::aid-mus13>3.0.co;2-#

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✦ Synopsis

We report the first case of stiff-persons' (-man) syndrome in the setting of a histologically proven thymoma. Muscular hyperactivity was abolished under general anesthesia and the symptoms of stiffness resolved after thymectomy and three courses of intravenous immunoglobulins. After thymectomy, the patient developed ocular myasthenia gravis which later resolved spontaneously. We suggest that thymoma be sought for in cases with neuromuscular hyperactivity syndromes. Myasthenia gravis may develop subsequently in these cases.

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