We investigated the therapeutic effects of milacemide in seven patients with myoclonus and three patients with the stiff-person syndrome in an open-label trial. Milacemide was initiated at 800 mg/day and was gradually increased to a maximum dosage of 2,400 mg/day. No significant improvement occurred
Stiff person syndrome: Advances in pathogenesis and therapeutic interventions
β Scribed by Marinos C. Dalakas
- Book ID
- 107558995
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 287 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1092-8480
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Stiff person syndrome (SPS) is a rare, chronic disorder characterized by painful spasm and stiffness. We investigated the quality of life (QoL) in SPS patients, and identified factors associated with impairment in patients' QoL. Twentyβfour SPS patients (10 men, 14 women; mean age Β± S.D
## Abstract We measured expression of central nervous system GABAβA receptors with ^11^Cβflumazenil (^11^CβFMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced ^11^CβFMZ binding potential (BP) in motorβpremotor cortex, and increased ^11^CβFMZ BP in the cerebellar nuclei.