Sterols that modify moulting in insects

✍ Scribed by Luu, Bang; Werner, Frederic

• Book ID: 101216190
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 362 KB
• Volume: 46
• Category: Article
• ISSN: 1526-498X
• DOI: 10.1002/(sici)1096-9063(199601)46:1<49::aid-ps340>3.0.co;2-4

✦ Synopsis

The development of insects is under the control of a steroid hormone, ecdysone. This paper reviews suicide substrate type inactivators designed to inhibit the biosynthesis of ecdysone. Several series of acetylenic derivatives of cholesterol were synthesized and their biological effects on the prothoracic glands of the locust were investigated in oitro, enabling structure-activity relationships to be studied.

Information on the ability of brassinosteroids, a series of plant growth regulators, to inhibit ecdysteroid activities of insects is discussed as a precursor to a study of brassinosteroid ecdysone mimics.