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Sterol Regulatory Element Binding Protein-Mediated Effect of Fluvastatin on Cytosolic 3-Hydroxy-3-methylglutaryl-Coenzyme A Synthase Transcription

✍ Scribed by Cristina Mascaró; José A. Ortiz; Ma Mercedes Ramos; Diego Haro; Fausto G. Hegardt


Book ID
115568009
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
167 KB
Volume
374
Category
Article
ISSN
0003-9861

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Cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase catalyzes the formation of HMG-CoA, the substrate for the rate-controlling enzyme in the cholesterol biosynthetic pathway. To explore the regulation in liver, we developed a new, accurate, and reliable reversed-phase ion-pair chromat