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Sterol and pH Interdependence in the Binding, Oligomerization, and Pore Formation of Listeriolysin O †

✍ Scribed by Bavdek, Andrej; Gekara, Nelson O.; Priselac, Dragan; Gutiérrez Aguirre, Ion; Darji, Ayub; Chakraborty, Trinad; Maček, Peter; Lakey, Jeremy H.; Weiss, Siegfried; Anderluh, Gregor


Book ID
121692199
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
483 KB
Volume
46
Category
Article
ISSN
0006-2960

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✍ Anderluh, Gregor; Lakey, Jeremy 📂 Article 📅 2010 🏛 Springer New York 🌐 English ⚖ 664 KB

Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps; proteins need to attach to the lipid mem