Steroids. Part I. Selective Hydrogenation of Ergosterol and its Acetate
✍ Scribed by Wadie Tadros; Adel Louis Boulos
- Book ID
- 102855472
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- German
- Weight
- 520 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0018-019X
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Selective hydrogenation of ergosterol or its acetate in solution in different solvents over Raney nickel to give 5α‐ergosta‐7,22‐dien‐3β‐ol or its acetate can be controlled by the addition of paraformaldehyde, acetaldehyde, benzaldehyde, 4‐dimethylaminobenzaldehyde, and dimethylaniline, the latter 2 giving the best yield. When using pure solvents 5α‐ergost‐7‐en‐3β‐ol or its acetate can be obtained in almost quantitative yield.
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Activated carbon cloth is impregnated by dipping in solutions of cobalt acetate or nickel acetate to give a range of loadings. Prepared cloths were used to form filter beds, 20 layers thick, which were exposed to hydrogen cyanide (HCN)-laden air. Challenge concentration was 2 mg L-' HCN in air at 80