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Steroidogenic factor 1 differentially regulates basal and inducible steroidogenic gene expression and steroid synthesis in human adrenocortical H295R cells

✍ Scribed by Lih-Ann Li; Yu-Cheng Chang; Chien-Jen Wang; Feng-Yuan Tsai; Shiang-Bin Jong; Bon-Chu Chung


Book ID
116697293
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
335 KB
Volume
91
Category
Article
ISSN
0960-0760

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The focus on the refinement, reduction and replacement of animal use in toxicity testing requires the development of cell-based systems that mimic the effects of xenobiotics in human tissues. The human adrenocortical carcinoma cell line, H295R, has been proposed as a model for studies on adrenal ste