✦ LIBER ✦
Steroide und Sexualhormone. 260. Mitteilung. Limonoide Bitterstoffe V. Untersuchungen zur Stereochemie der C(8)-Alkylierung von 7-Oxo-13,17-secosteroiden
✍ Scribed by Hans-Rudolf Schlatter; Walter Graf
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- German
- Weight
- 493 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
On the Stereochemistry of the C(8)‐Alkylation of 7‐Oxo‐13,17‐secosteroids
It is shown that the title compounds, e.g. 10, can be alkylated with methyl iodide under strongly basic conditions to afford 8α‐methylated products, e.g. 11 (Scheme 1). The configuration was assigned by ^13^C‐NMR.‐spectroscopy, CD. measurements, and finally proved by a X‐ray crystallographic structure analysis.