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Steroidal Hormone Relatives. II. 1 The Synthesis of 4-(m-Carboxyphenyl)-3-(p-hydroxyphenyl)-2-hexanone

โœ Scribed by Burckhalter, J. H.; Jackson, Peter H.; Sam, Joseph; Meyer, Hans R.


Book ID
125961398
Publisher
American Chemical Society
Year
1954
Tongue
English
Weight
527 KB
Volume
76
Category
Article
ISSN
0002-7863

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Synthesis of N- Substituted 4-(4-Hydroxy
โœ Guzikowski, Anthony P.; Tamiz, Amir P.; Acosta-Burruel, Manuel; Hong-Bae, Soo; C ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› American Chemical Society ๐ŸŒ English โš– 337 KB

Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ฯ‰-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent