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Steroid-responsive multifocal demyelinating neuropathy with central involvement

✍ Scribed by Rocco Liguori; Romana Rizzi; Roberto Vetrugno; Fabrizio Salvi; Alessandra Lugaresi; Sabina Cevoli; Pasquale Montagna

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 108 KB
Volume: 22
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199902)22:2<262::aid-mus16>3.0.co;2-1

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✦ Synopsis

We describe 2 patients with associated central and peripheral demyelination. Electrophysiological studies revealed a demyelinating polyneuropathy with sensory and motor conduction blocks. Visual evoked potentials were abnormal. Motor evoked potentials showed abnormal central conduction time in 1 patient. Magnetic resonance imaging revealed regions of abnormal high signal in the spinal cord and brain; sural nerve biopsy disclosed a demyelinating neuropathy. Both patients showed clinical and electrophysiological improvement after steroid therapy.

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