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Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer

✍ Scribed by Line L Haugan Moi, Marianne Hauglid Flågeng, Jennifer Gjerde, Andre Madsen, Therese Halvorsen Røst, Oddrun Anita Gudbrandsen, Ernst A Lien, Gunnar Mellgren


Book ID
119897311
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
298 KB
Volume
12
Category
Article
ISSN
1471-2407

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## Abstract Overexpression of Her2/neu is implicated in the development of resistance to the antiestrogen tamoxifen (TAM) that exerts its inhibitory effect through interaction with estrogen receptor (ER). Whereas Her2/neu and ER are believed to be important cell survival/death factors in human brea