Members of the p160 steroid receptor cofactor family, including AIB1 (Amplified in Breast Cancer 1) (also known as SRC-3/RAC3/ACTR/pCIP/TRAM-1), are of interest in endometrial carcinoma as they affect the function of estrogen (ER) and progesterone receptors (PR). Since it is feasible that alteration
Steroid receptor coactivator AIB1 in endometrial carcinoma, hyperplasia and normal endometrium: correlation with clinicopathologic parameters and biomarkers
β Scribed by Balmer, Nicole N; Richer, Jennifer K; Spoelstra, Nicole S; Torkko, Kathleen C; Lyle, Pamela L; Singh, Meenakshi
- Book ID
- 109888515
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 424 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0893-3952
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## Abstract ## BACKGROUND To examine the steroid hormone dependent growth mechanism of human endometrial hyperplasia and carcinoma, expression levels of steroid receptor cofactors, such as coactivators (steroid receptor coactivator 1 [SRCβ1] and p300/cyclic AMPβresponse elementβbinding protein (p3
Using immunohistochemistry, we examined pS2 expression in 64 samples of endometrial carcinoma, 11 samples of endometrial hyperplasia and 15 samples of normal endometrium, and compared them with clinicopathological data, estrogen receptor (ER) expression and progesterone receptor (PR) expression. Of